The most important thing: Cannabis laws vary extremely around the world: from full legalization (Canada, Uruguay) to the death penalty (Singapore, Malaysia). Since April 2024, Germany has been one of the few countries in the EU with limited recreational legalization. At a glance: Germany since April 2024: possession up to 25 g and 3 plants […]
The most important thing: cannabis smoke contains the same toxins as tobacco smoke (CO, PAH, benzene, tar) – but there is no evidence of an increased risk of lung cancer. Chronic bronchitis is well documented. Vaporizer solves both problems. At a glance: Cannabis smoke = same toxins as tobacco (CO, PAH, benzene) – but no […]
Most importantly, the ECS regulates extinction learning and habitualization – precisely the processes that are dysfunctional in OCD. CB1 in the orbitofrontal cortex and striatum inhibits the hyperactive CSTC circuit typical of OCD. At a glance: CB1 in the orbitofrontal cortex and striatum inhibits the OCD-typical hyperactive CSTC circuit Kayser 2021: Nabilone (synthetic THC) significantly […]
The most important thing: CBD lowers blood pressure, THC increases it in the short term. Jadoon 2017 (RCT, n=9): Single CBD dose 600 mg lowered systolic blood pressure at rest by -6 mmHg. Over 30 million Germans have hypertension. At a glance: CBD lowers blood pressure: -6 mmHg systolic at rest (Jadoon 2017, RCT) and […]
The most important thing: all mammals have an ECS. But dogs are hypersensitive to THC: significantly more CB1 receptors in the cerebellum than humans, slower metabolization. Even small amounts of THC can lead to severe intoxication. At a glance: Dogs have significantly more CB1 receptors in the cerebellum than humans – THC is toxic to […]
The most important thing: Cannabis social clubs (cultivation associations) have been legal in Germany since July 1, 2024. Up to 500 members, non-profit, maximum 25 g distribution/day or 50 g/month. No sale – only cost recovery. At a glance: Legal since July 1, 2024 – maximum 500 members, non-profit, distribution up to 25 g/day No […]
Most important: Tinnitus is one of the few indications where cannabis may NOT help: CB1 activation in the dorsal cochlear nucleus can increase tinnitus-like activity. Bhatt 2020: Cannabis use associated with increased risk of tinnitus. At a glance: CB1 receptors in auditory cortex and cochlear nuclei – but cannabis can worsen tinnitus Bhatt 2020: Cannabis […]
The most important thing: CBGA is the biosynthetic precursor of all cannabinoids – less than 1% CBG remains in mature plants. Farha 2020: CBG destroyed MRSA biofilms more effectively than many standard antibiotics. At a glance: CBGA is biosynthetic precursor of all cannabinoids – less than 1% CBG left in mature plants Farha 2020: CBG […]
The most important thing: the ECS changes with age: CB1 receptor density decreases, anandamide decreases. People over 65 are the fastest growing group when it comes to medicinal cannabis – and often react more strongly to cannabinoids. At a glance: CB1 receptor density decreases with age – older people react more strongly to cannabinoids Over […]
The most important thing: Chronic stress downregulates CB1 receptors in the prefrontal cortex and hippocampus – directly measurable in burnout pathophysiology. CBD modulates the HPA axis and can lower basal cortisol levels. At a glance: Chronic stress → CB1 downregulation in the prefrontal cortex – measurable ECS deficit in burnout CBD modulates HPA axis and […]
The Gulfstream G650ER is more than just an airplane – it is the symbol of freedom of movement at the highest level. With a range of over 13,000 kilometers and a cruising speed close to Mach 0.9, it is one of the fastest and most far-reaching private jets in the world. Kim Kardashian, Oprah Winfrey, […]
The most important thing: CBN is produced by THC oxidation – not by extraction. CBN alone has no measurable sleep effect. Only CBN+THC combined is measurably more sedating than THC alone (Musty 1976). Many CBN products exaggerate. At a glance: CBN alone = no measurable sleep effect – only CBN+THC combined significantly more sedative CBN […]
The most important thing: THC is a recognized risk factor for mania triggers in bipolar disorder. 40% of bipolar patients use cannabis for self-medication – mostly for depressive phases. Psychiatric consultation is mandatory. At a glance: THC in bipolar disorder = risk factor for mania triggers – no attempt to self-medicate with THC 40% of […]
Most importantly, Alzheimer’s patients have reduced anandamide levels and downregulated CB1 receptors in the entorhinal cortex. CBD inhibits amyloid-β aggregation and tau hyperphosphorylation – both core drivers of the disease. At a glance: CBD inhibits amyloid-β aggregation and tau hyperphosphorylation (in vitro and animal model) CB2 on microglial cells: Cannabis reduces neuroinflammation – a core […]
Most important: CB2 receptors are located directly on inflamed synovial cells and chondrocytes in rheumatism. Blake 2006 (RCT, n=58): Nabiximols significantly better than placebo for pain and disease activity (DAS28). At a glance: CB2 is directly expressed on synovial cells and chondrocytes – cannabis attacks at the site of inflammation Blake 2006 (RCT, n=58): Nabiximols […]
The most important thing: THC inhibits CGRP release from trigeminal nerve endings – the same target as modern migraine biologics (Aimovig, Emgality). Rhyne 2016: Migraine frequency decreased from 10.4 to 4.6 attacks/month (-56 %). At a glance: THC inhibits CGRP – the same target as migraine biologics (Aimovig, Emgality) Rhyne 2016 (n=121): -56% migraine frequency […]
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