The most important thing: THC is converted in the liver to 11-hydroxy-THC – a metabolite that is up to 3× stronger than THC itself. This explains why edibles have a more intense effect and why topping up after 45 minutes is the classic mistake. At a glance: THC → 11-hydroxy-THC in the liver: up to […]
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Most importantly, alcohol significantly increases gastrointestinal THC absorption. Cannabis + alcohol is not additive – but synergistic. Hartman 2015: The combination doubles driving impairment compared to cannabis alone. At a glance: Alcohol significantly increases the THC plasma concentration (Cmax) – the same dose has a more intensive combined effect Combination of cannabis + alcohol = […]
Private jets are as commonplace for the world’s richest people as cabs are for the rest of us. While we stand in queues, show boarding passes and smuggle miniature shampoos through security checks, Hollywood stars, billionaires and music legends walk straight from their cars onto their own planes. No check-in, no crowds, no schedule except […]
Most importantly, IBS affects 10-15% of the population. IBS patients have increased FAAH activity and lower anandamide levels in the intestine – a measurable ECS deficit directly at the site of the symptoms. At a glance: IBS patients have increased FAAH activity and lower anandamide levels in the gut – measurable ECS deficit CB1 on […]
Professional teeth cleaning (PZR) is one of the most important preventive measures for healthy teeth – but the costs are not usually covered by statutory health insurance. What does a PZR really cost, what are the annual costs and when is supplementary dental insurance worthwhile? New from us: Your comparison portal on dental insurance One. […]
Most importantly, endometriosis lesions express CB1 and CB2 at lower levels than normal endometrium – an ECS hypoactivity directly at the pathology site. CBD inhibited proliferation and invasion of lesions in vitro (Bouaziz 2017). At a glance: Endometriosis lesions express CB1 and CB2 – ECS directly involved in pathophysiology CBD inhibited proliferation and invasion of […]
Cologne, February 2026: Hundreds of young people are queuing up to impress Heidi Klum. Nothing new on Germany’s Next Topmodel, really. But then Jean Paul Gaultier enters the room and suddenly a casting turns into a fashion event. The French couturier, known for his provocative designs and unmistakable style, personally helped Heidi select the new […]
A new chapter in the history of Germany’s Next Topmodel began on February 15, 2024. Not because the casting show entered its 19th round, but because Heidi Klum brought men onto the catwalk for the first time. What was announced as a bold step turned out to be perhaps the most exciting season since Lena […]
20 seasons of Germany’s Next Topmodel. Two decades in which Heidi Klum sent hundreds of young talents onto the catwalk. In 2025, the show celebrated this anniversary in its very own way: with a season that spanned from the early days to the present day and ultimately crowned two winners who could hardly be more […]
The most important thing: The classic indica/sativa classification is botanical, not pharmacological – and scientifically outdated. The effect depends on the terpene profile: myrcene = sedative, limonene = activating, linalool = anxiolytic. At a glance: Indica/sativa classification is botanical, not pharmacological – scientifically outdated Effect depends on terpene profile: myrcene = sedative, limonene = activating, […]
The most important thing: THC limit of 3.5 ng/ml in blood serum has applied since August 22, 2024. In combination with alcohol: limit drops to 1 ng/ml. Chronic users can be above the limit for days. At a glance: Since August 22, 2024: THC limit of 3.5 ng/ml in blood serum – replaces the previous […]
The most important thing: THC crosses the placental barrier without any problems. The fetal ECS already develops in the first trimester. No known safe limit – the only evidence-based limit is total abstinence. At a glance: THC crosses the placental barrier and binds to CB1 receptors in the fetal brain from the first trimester onwards […]
Most important: The brain develops until 25 – endocannabinoids control pruning and myelination. Meier 2012 (n=1037, Dunedin cohort): Start before 15 = 8 IQ point loss by 38. Adults who started after 18: no significant loss. At a glance: Brain development up to 25 – endocannabinoids control pruning and myelination, THC disrupts these processes Meier […]
The most important thing: CBD has been WADA-approved since 2018. Cannabis intervenes in inflammatory processes via CB2 and in pain modulation via CB1 – both relevant for regeneration. 26% of recreational athletes already use cannabis for regeneration. At a glance: CBD WADA-approved since 2018 – THC remains banned in competition (150 ng/ml urine) CBD via […]
Most important: CB1 is expressed in genital tissue, hypothalamus and limbic system. Cannabis has a biphasic effect: low doses increase libido and sensitivity, high doses inhibit them. Sun 2017 (n=28,000): Cannabis users had more sex in all groups. At a glance: CB1 in genital tissue, hypothalamus and limbic system – ECS directly integrated into sexual […]
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