The most important thing: Delta-8-THC is not a natural cannabis substance – it is almost exclusively produced synthetically from CBD. FDA analysis 2021 found dangerous impurities. In Germany it is not “legal THC” – legally it is considered a narcotic. At a glance: Delta-8-THC hardly occurs naturally in plants – almost all products are produced […]
The most important thing: vaporizers deliver 40-56 % bioavailability compared to 25 % with a joint – without tar, without CO, without benzenes. For medical users, vaporizer or sublingual oil is the most pharmacologically sensible way. At a glance: Vaporizer delivers 40-56 % bioavailability – more than twice as efficient as a joint Sublingual oil: […]
The most important thing: although cannabis increases appetite, users have on average 25% lower obesity rates than non-users. Background: chronic use leads to CB1 downregulation and increased adiponectin. At a glance: Paradox: Cannabis users have 25% lower obesity rates than non-users Chronic use → CB1 downregulation → Metabolic reset of the ECS CBD converts white […]
The most important thing: CBD inhibits COX-2 – the same enzyme as ibuprofen – and activates CB1 receptors directly in the uterine muscles. It also has an anxiolytic effect via 5-HT1A. Survey data show 7.6/10 efficacy for menstrual pain. At a glance: CBD inhibits COX-2 – the same mechanism as ibuprofen, but without gastrointestinal risk […]
The most important thing: According to the study, full-spectrum cannabis requires a lower dose for the same epilepsy control as CBD isolate (Pamplona 2018). Why? Cannabinoids, terpenes and flavonoids work synergistically – this is the entourage effect. At a glance: Full-spectrum needs lower dose than CBD isolate for same effect, according to study Terpenes such […]
The most important thing: oestrogen directly regulates anandamide levels in the brain. If oestrogen falls during the menopause, anandamide also falls – which explains hot flushes, sleep disorders and mood swings neurobiologically. At a glance: Oestrogen directly regulates anandamide levels – menopause = ECS dysregulation 79% of women surveyed report symptom relief from cannabis (Dahlgren […]
The most important thing: THC is converted in the liver to 11-hydroxy-THC – a metabolite that is up to 3× stronger than THC itself. This explains why edibles have a more intense effect and why topping up after 45 minutes is the classic mistake. At a glance: THC → 11-hydroxy-THC in the liver: up to […]
Most importantly, alcohol significantly increases gastrointestinal THC absorption. Cannabis + alcohol is not additive – but synergistic. Hartman 2015: The combination doubles driving impairment compared to cannabis alone. At a glance: Alcohol significantly increases the THC plasma concentration (Cmax) – the same dose has a more intensive combined effect Combination of cannabis + alcohol = […]
Private jets are as commonplace for the world’s richest people as cabs are for the rest of us. While we stand in queues, show boarding passes and smuggle miniature shampoos through security checks, Hollywood stars, billionaires and music legends walk straight from their cars onto their own planes. No check-in, no crowds, no schedule except […]
Most importantly, IBS affects 10-15% of the population. IBS patients have increased FAAH activity and lower anandamide levels in the intestine – a measurable ECS deficit directly at the site of the symptoms. At a glance: IBS patients have increased FAAH activity and lower anandamide levels in the gut – measurable ECS deficit CB1 on […]
Professional teeth cleaning (PZR) is one of the most important preventive measures for healthy teeth – but the costs are not usually covered by statutory health insurance. What does a PZR really cost, what are the annual costs and when is supplementary dental insurance worthwhile? New from us: Your comparison portal on dental insurance One. […]
Most importantly, endometriosis lesions express CB1 and CB2 at lower levels than normal endometrium – an ECS hypoactivity directly at the pathology site. CBD inhibited proliferation and invasion of lesions in vitro (Bouaziz 2017). At a glance: Endometriosis lesions express CB1 and CB2 – ECS directly involved in pathophysiology CBD inhibited proliferation and invasion of […]
Cologne, February 2026: Hundreds of young people are queuing up to impress Heidi Klum. Nothing new on Germany’s Next Topmodel, really. But then Jean Paul Gaultier enters the room and suddenly a casting turns into a fashion event. The French couturier, known for his provocative designs and unmistakable style, personally helped Heidi select the new […]
A new chapter in the history of Germany’s Next Topmodel began on February 15, 2024. Not because the casting show entered its 19th round, but because Heidi Klum brought men onto the catwalk for the first time. What was announced as a bold step turned out to be perhaps the most exciting season since Lena […]
20 seasons of Germany’s Next Topmodel. Two decades in which Heidi Klum sent hundreds of young talents onto the catwalk. In 2025, the show celebrated this anniversary in its very own way: with a season that spanned from the early days to the present day and ultimately crowned two winners who could hardly be more […]
The most important thing: The classic indica/sativa classification is botanical, not pharmacological – and scientifically outdated. The effect depends on the terpene profile: myrcene = sedative, limonene = activating, linalool = anxiolytic. At a glance: Indica/sativa classification is botanical, not pharmacological – scientifically outdated Effect depends on terpene profile: myrcene = sedative, limonene = activating, […]
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