The most important thing: Restless legs syndrome (RLS) affects 5-10% of the population and is often resistant to treatment. Cannabis intervenes directly in RLS pathophysiology via dopaminergic modulation (CB1 in basal ganglia) and spinal pain processing (TRPV1). At a glance: RLS affects 5-10% of the population and is treatment-resistant in many cases Ghorayeb 2020: 6 […]
The most important thing: CBN is formed when THC oxidizes – through UV light, oxygen and heat over months. Old cannabis contains more CBN. CBN is weakly psychoactive and has a sedative effect mainly in combination with THC – not alone. At a glance: CBN is produced exclusively by oxidation of THC – UV light, […]
The most important thing: oestrogen directly regulates anandamide levels in the brain. If oestrogen falls during the menopause, anandamide also falls – which explains hot flushes, sleep disorders and mood swings neurobiologically. At a glance: Oestrogen directly regulates anandamide levels – menopause = ECS dysregulation 79% of women surveyed report symptom relief from cannabis (Dahlgren […]
Most importantly, fibromyalgia patients have been shown to have lower levels of anandamide in the CSF – a direct ECS deficit. CEDS theory (Russo 2016): Fibromyalgia, migraine and irritable bowel syndrome may be endocannabinoid-deficient disorders. At a glance: Fibromyalgia patients have been shown to have lower anandamide levels – direct ECS deficit in CSF CEDS […]
The most important thing: THC shortens sleep onset time, suppresses REM sleep and increases deep sleep. CBD high dose (160+ mg) increases total sleep time. After T-break: REM rebound with intense dreams for 1-3 weeks. At a glance: THC: shortens sleep onset time, suppresses REM, increases deep sleep – good in the short term, problematic […]
The most important thing: the ECS changes with age: CB1 receptor density decreases, anandamide decreases. People over 65 are the fastest growing group when it comes to medicinal cannabis – and often react more strongly to cannabinoids. At a glance: CB1 receptor density decreases with age – older people react more strongly to cannabinoids Over […]
The most important thing: CBN is produced by THC oxidation – not by extraction. CBN alone has no measurable sleep effect. Only CBN+THC combined is measurably more sedating than THC alone (Musty 1976). Many CBN products exaggerate. At a glance: CBN alone = no measurable sleep effect – only CBN+THC combined significantly more sedative CBN […]
Bedroom properly furnish & decorate – The bedroom is considered the sanctuary of the home. Here energy is refuelled, the morning is started and in the evening the long working day is forgotten. Restful sleep is the be-all and end-all for everyone. We’ll show you here how to furnish and decorate your bedroom properly so […]
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