The most important thing: Chronic back pain has four types of pain (nociceptive, neuropathic, myofascial, centralized) – cannabis attacks all four at the same time. 70% of patients report a strong reduction. And: cannabis can reduce opioid requirements by 44 %. At a glance: Cannabis simultaneously targets all 4 types of pain: nociceptive, neuropathic, myofascial, […]
Most importantly, social anxiety is the best clinically proven cannabis indication. Bergamaschi 2011 (RCT): CBD 600 mg measurably halved anxiety, cognitive impairment and physiological stress during public speaking. THC, on the other hand, can increase social anxiety. At a glance: Bergamaschi 2011 (RCT): CBD 600 mg halved anxiety, cognitive impairment and stress Optimal dose: 300 […]
The most important thing: Daily cannabis use is a problem when trying to conceive: Gundersen 2015 shows up to 52% lower sperm concentration. All effects are reversible after 3 months of abstinence – spermatogenesis takes 74 days. At a glance: Weekly consumption: 28% lower sperm concentration (Gundersen 2015, n=1215) All sperm effects completely reversible after […]
The most important thing: THC has a biphasic effect: 1-5 mg can have an anxiolytic and focusing effect. 20-25 mg+ can trigger paranoia and anxiety. Anyone using cannabis for medicinal purposes needs a minimum dose – not a maximum. At a glance: THC has a biphasic effect: 1-5 mg anxiolytic and focusing, 20+ mg can […]
Most important: 20-30% of all adults with ADHD self-medicate with cannabis. Pharmacologically plausible: ADHD is associated with anandamide deficiency, CB1 directly modulates dopamine. Survey data shows 55% report better concentration. At a glance: 20-30% of all adults with ADHD self-medicate with cannabis Mechanism: ADHD is associated with anandamide deficiency – CB1 directly modulates dopamine For […]
The most important thing: raw cannabis flowers do not get you high. THCA (the natural form) hardly binds to CB1 receptors. Only heat (120°C, 35 min) produces active THC through decarboxylation. This happens automatically when smoking. At a glance: Raw cannabis does not get you high – THCA hardly binds to CB1 receptors Optimal decarboxylation: […]
The most important thing: THC increases the heart rate by 20-50 bpm by activating the sympathetic nervous system. In healthy boys: harmless. In coronary heart disease: risk of heart attack increases 4.8-fold in the first hour. CBD, on the other hand, lowers blood pressure. At a glance: THC increases the heart rate by 20-50 bpm […]
The most important thing: Hirvonen 2012 PET study: Daily cannabis users have 15-20% fewer CB1 receptors in the cortex. This is the neurobiological cause of tolerance. After 4 weeks of abstinence: measurable recovery of receptor density. At a glance: PET study: daily users have 15-20% fewer CB1 receptors in the cortex (Hirvonen 2012) After 4 […]
The most important thing: cannabis reduces the need for opioids in palliative patients by a median of 44% (Mechnik 2018). Dronabinol and nabilone are approved for chemotherapy nausea. Since 2017 on BtMG prescription with SHI reimbursement option. At a glance: Dronabinol (THC) and nabilone are officially approved for chemotherapy nausea Cannabis reduces the need for […]
The most important thing: although cannabis increases appetite, users have on average 25% lower obesity rates than non-users. Background: chronic use leads to CB1 downregulation and increased adiponectin. At a glance: Paradox: Cannabis users have 25% lower obesity rates than non-users Chronic use → CB1 downregulation → Metabolic reset of the ECS CBD converts white […]
The most important thing: According to the study, full-spectrum cannabis requires a lower dose for the same epilepsy control as CBD isolate (Pamplona 2018). Why? Cannabinoids, terpenes and flavonoids work synergistically – this is the entourage effect. At a glance: Full-spectrum needs lower dose than CBD isolate for same effect, according to study Terpenes such […]
The most important thing: THC is converted in the liver to 11-hydroxy-THC – a metabolite that is up to 3× stronger than THC itself. This explains why edibles have a more intense effect and why topping up after 45 minutes is the classic mistake. At a glance: THC → 11-hydroxy-THC in the liver: up to […]
The most important thing: THC limit of 3.5 ng/ml in blood serum has applied since August 22, 2024. In combination with alcohol: limit drops to 1 ng/ml. Chronic users can be above the limit for days. At a glance: Since August 22, 2024: THC limit of 3.5 ng/ml in blood serum – replaces the previous […]
The most important thing: THC crosses the placental barrier without any problems. The fetal ECS already develops in the first trimester. No known safe limit – the only evidence-based limit is total abstinence. At a glance: THC crosses the placental barrier and binds to CB1 receptors in the fetal brain from the first trimester onwards […]
Most important: The brain develops until 25 – endocannabinoids control pruning and myelination. Meier 2012 (n=1037, Dunedin cohort): Start before 15 = 8 IQ point loss by 38. Adults who started after 18: no significant loss. At a glance: Brain development up to 25 – endocannabinoids control pruning and myelination, THC disrupts these processes Meier […]
Most important: CB1 is expressed in genital tissue, hypothalamus and limbic system. Cannabis has a biphasic effect: low doses increase libido and sensitivity, high doses inhibit them. Sun 2017 (n=28,000): Cannabis users had more sex in all groups. At a glance: CB1 in genital tissue, hypothalamus and limbic system – ECS directly integrated into sexual […]
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