Key points: In vitro and in animal models, cannabinoids inhibit tumor growth, angiogenesis and metastasis. In humans: no clinical evidence for cancer cure. Cannabis in cancer is well documented for symptom control (pain, nausea, appetite). At a glance: In vitro: Cannabinoids inhibit tumor growth, angiogenesis and metastasis in dozens of cell lines Guzman 2006: Intratumoral […]
Most important: Dronabinol (synthetic THC) received FDA approval in 1985 for chemotherapy nausea – one of the oldest medical cannabis indications. CB1 in the vomiting center (area postrema) directly inhibits the serotonergic nausea signaling cascade. At a glance: Dronabinol FDA-approved for chemotherapy nausea since 1985 – one of the oldest cannabis indications CB1 in the […]
Most importantly, fibromyalgia patients have been shown to have lower levels of anandamide in the CSF – a direct ECS deficit. CEDS theory (Russo 2016): Fibromyalgia, migraine and irritable bowel syndrome may be endocannabinoid-deficient disorders. At a glance: Fibromyalgia patients have been shown to have lower anandamide levels – direct ECS deficit in CSF CEDS […]
The most important thing: CBD lowers blood pressure, THC increases it in the short term. Jadoon 2017 (RCT, n=9): Single CBD dose 600 mg lowered systolic blood pressure at rest by -6 mmHg. Over 30 million Germans have hypertension. At a glance: CBD lowers blood pressure: -6 mmHg systolic at rest (Jadoon 2017, RCT) and […]
The most important thing: THC is a recognized risk factor for mania triggers in bipolar disorder. 40% of bipolar patients use cannabis for self-medication – mostly for depressive phases. Psychiatric consultation is mandatory. At a glance: THC in bipolar disorder = risk factor for mania triggers – no attempt to self-medicate with THC 40% of […]
Four types of cannabis, four different effects – but which one is right for you? Find out what distinguishes sativa, indica, hybrid and ruderalis and why each strain is unique! Learn more about cannabis strains here. Sativa, Indica, Hybrid & Ruderalis 𥦠Super briefly explained Cannabis comes in four main varieties, which differ in growth, […]
Did you know that cannabis was used as a medicinal plant over 4,000 years ago? The plant, which is often the subject of controversy today, was once a valued remedy in many cultures. From China to Egypt to Greece – doctors and healers everywhere discovered the versatile effects of the various cannabis varieties. Whether as […]
The terms “cannabis” and “medicinal cannabis” are often used to describe two different uses of the plant. Although both terms refer to the same plant, there are significant differences in their use, regulation and effects. Here we explain what you need to know about cannabis in general and medicinal cannabis and how they differ. What […]
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