The most important thing: the ECS changes with age: CB1 receptor density decreases, anandamide decreases. People over 65 are the fastest growing group when it comes to medicinal cannabis – and often react more strongly to cannabinoids. At a glance: CB1 receptor density decreases with age – older people react more strongly to cannabinoids Over […]
The most important thing: Chronic stress downregulates CB1 receptors in the prefrontal cortex and hippocampus – directly measurable in burnout pathophysiology. CBD modulates the HPA axis and can lower basal cortisol levels. At a glance: Chronic stress → CB1 downregulation in the prefrontal cortex – measurable ECS deficit in burnout CBD modulates HPA axis and […]
The most important thing: THC is a recognized risk factor for mania triggers in bipolar disorder. 40% of bipolar patients use cannabis for self-medication – mostly for depressive phases. Psychiatric consultation is mandatory. At a glance: THC in bipolar disorder = risk factor for mania triggers – no attempt to self-medicate with THC 40% of […]
Most importantly, Alzheimer’s patients have reduced anandamide levels and downregulated CB1 receptors in the entorhinal cortex. CBD inhibits amyloid-β aggregation and tau hyperphosphorylation – both core drivers of the disease. At a glance: CBD inhibits amyloid-β aggregation and tau hyperphosphorylation (in vitro and animal model) CB2 on microglial cells: Cannabis reduces neuroinflammation – a core […]
Most important: CB2 receptors are located directly on inflamed synovial cells and chondrocytes in rheumatism. Blake 2006 (RCT, n=58): Nabiximols significantly better than placebo for pain and disease activity (DAS28). At a glance: CB2 is directly expressed on synovial cells and chondrocytes – cannabis attacks at the site of inflammation Blake 2006 (RCT, n=58): Nabiximols […]
The terms “cannabis” and “medicinal cannabis” are often used to describe two different uses of the plant. Although both terms refer to the same plant, there are significant differences in their use, regulation and effects. Here we explain what you need to know about cannabis in general and medicinal cannabis and how they differ. What […]
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