The most important thing: CBD has been WADA-approved since 2018. Cannabis intervenes in inflammatory processes via CB2 and in pain modulation via CB1 – both relevant for regeneration. 26% of recreational athletes already use cannabis for regeneration. At a glance: CBD WADA-approved since 2018 – THC remains banned in competition (150 ng/ml urine) CBD via […]
Most important: CB1 is expressed in genital tissue, hypothalamus and limbic system. Cannabis has a biphasic effect: low doses increase libido and sensitivity, high doses inhibit them. Sun 2017 (n=28,000): Cannabis users had more sex in all groups. At a glance: CB1 in genital tissue, hypothalamus and limbic system – ECS directly integrated into sexual […]
Most importantly, the skin is one of the tissues most densely endowed with ECS components. CB2 on keratinocytes and mast cells regulates inflammation, proliferation and sebum – all of which are dysregulated in psoriasis. At a glance: CB2 on keratinocytes and mast cells regulates inflammation, proliferation and sebum directly in the skin CBD significantly inhibited […]
The most important thing: CB1 is particularly dense in the striatum, globus pallidus and substantia nigra – precisely the structures that degenerate in Parkinson’s disease. Lotan 2014 (n=22): Cannabis reduced tremor by -31% and pain by -45%. At a glance: CB1 is particularly dense in the striatum, globus pallidus and substantia nigra – at the […]
Key points: In vitro and in animal models, cannabinoids inhibit tumor growth, angiogenesis and metastasis. In humans: no clinical evidence for cancer cure. Cannabis in cancer is well documented for symptom control (pain, nausea, appetite). At a glance: In vitro: Cannabinoids inhibit tumor growth, angiogenesis and metastasis in dozens of cell lines Guzman 2006: Intratumoral […]
Most important: ASD patients have altered endocannabinoid levels and CB1 expression. Aran 2019 (n=60): CBD-rich cannabis oil (80% CBD, 1% THC) improved behavioral problems in 74% of children. At a glance: ASD patients show lower anandamide levels and altered CB1 expression Aran 2019 (n=60): 74% of children showed improvement in behavioral problems with CBD-rich oil […]
Most important: Dronabinol (synthetic THC) received FDA approval in 1985 for chemotherapy nausea – one of the oldest medical cannabis indications. CB1 in the vomiting center (area postrema) directly inhibits the serotonergic nausea signaling cascade. At a glance: Dronabinol FDA-approved for chemotherapy nausea since 1985 – one of the oldest cannabis indications CB1 in the […]
Most importantly, fibromyalgia patients have been shown to have lower levels of anandamide in the CSF – a direct ECS deficit. CEDS theory (Russo 2016): Fibromyalgia, migraine and irritable bowel syndrome may be endocannabinoid-deficient disorders. At a glance: Fibromyalgia patients have been shown to have lower anandamide levels – direct ECS deficit in CSF CEDS […]
Most important: Cannabis smoking is contraindicated in asthma and COPD. But: THC has bronchodilatory properties via CB1 on bronchial muscle cells. Vaporizers are the only sensible form of inhalation for lung diseases. At a glance: THC has bronchodilatory effect via CB1 – but ONLY when not smoked Cannabis smoking: contraindicated in asthma and COPD – […]
The most important thing: CBD has no standard dosage. Optimal dose depends on indication, body weight, CYP metabolism and form of administration. U-shaped dose-response curve: for anxiety, 300 mg is better than 600 mg. At a glance: CBD has no standard dosage – optimal dose is indication- and person-specific U-shaped effect curve for anxiety: 300 […]
The most important thing: 9% of users develop a cannabis addiction – compared to 32% for nicotine, 23% for heroin and 15% for alcohol. Daily users: 25-50 % risk. Dependence is real, but substance-specific lower. At a glance: 9% of users develop dependence (vs. 32% nicotine, 23% heroin, 15% alcohol) Daily use: 25-50% risk of […]
The most important thing: THC shortens sleep onset time, suppresses REM sleep and increases deep sleep. CBD high dose (160+ mg) increases total sleep time. After T-break: REM rebound with intense dreams for 1-3 weeks. At a glance: THC: shortens sleep onset time, suppresses REM, increases deep sleep – good in the short term, problematic […]
Most importantly, the ECS regulates extinction learning and habitualization – precisely the processes that are dysfunctional in OCD. CB1 in the orbitofrontal cortex and striatum inhibits the hyperactive CSTC circuit typical of OCD. At a glance: CB1 in the orbitofrontal cortex and striatum inhibits the OCD-typical hyperactive CSTC circuit Kayser 2021: Nabilone (synthetic THC) significantly […]
The most important thing: CBD lowers blood pressure, THC increases it in the short term. Jadoon 2017 (RCT, n=9): Single CBD dose 600 mg lowered systolic blood pressure at rest by -6 mmHg. Over 30 million Germans have hypertension. At a glance: CBD lowers blood pressure: -6 mmHg systolic at rest (Jadoon 2017, RCT) and […]
The most important thing: all mammals have an ECS. But dogs are hypersensitive to THC: significantly more CB1 receptors in the cerebellum than humans, slower metabolization. Even small amounts of THC can lead to severe intoxication. At a glance: Dogs have significantly more CB1 receptors in the cerebellum than humans – THC is toxic to […]
Most important: Tinnitus is one of the few indications where cannabis may NOT help: CB1 activation in the dorsal cochlear nucleus can increase tinnitus-like activity. Bhatt 2020: Cannabis use associated with increased risk of tinnitus. At a glance: CB1 receptors in auditory cortex and cochlear nuclei – but cannabis can worsen tinnitus Bhatt 2020: Cannabis […]
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