The most important thing: Chronic back pain has four types of pain (nociceptive, neuropathic, myofascial, centralized) – cannabis attacks all four at the same time. 70% of patients report a strong reduction. And: cannabis can reduce opioid requirements by 44 %. At a glance: Cannabis simultaneously targets all 4 types of pain: nociceptive, neuropathic, myofascial, […]
Most importantly, social anxiety is the best clinically proven cannabis indication. Bergamaschi 2011 (RCT): CBD 600 mg measurably halved anxiety, cognitive impairment and physiological stress during public speaking. THC, on the other hand, can increase social anxiety. At a glance: Bergamaschi 2011 (RCT): CBD 600 mg halved anxiety, cognitive impairment and stress Optimal dose: 300 […]
The most important thing: Restless legs syndrome (RLS) affects 5-10% of the population and is often resistant to treatment. Cannabis intervenes directly in RLS pathophysiology via dopaminergic modulation (CB1 in basal ganglia) and spinal pain processing (TRPV1). At a glance: RLS affects 5-10% of the population and is treatment-resistant in many cases Ghorayeb 2020: 6 […]
The most important thing: CB2 receptors – the non-psychoactive cannabinoid receptor class – are located directly on osteoblasts and osteoclasts. CB2 activation promotes bone formation and inhibits bone resorption. CBD significantly accelerated fracture healing in animal models. At a glance: CB2 receptors are located directly on osteoblasts (bone formation) and osteoclasts (bone resorption) CB2 knockout […]
The most important thing: THC has a biphasic effect: 1-5 mg can have an anxiolytic and focusing effect. 20-25 mg+ can trigger paranoia and anxiety. Anyone using cannabis for medicinal purposes needs a minimum dose – not a maximum. At a glance: THC has a biphasic effect: 1-5 mg anxiolytic and focusing, 20+ mg can […]
Most important: 20-30% of all adults with ADHD self-medicate with cannabis. Pharmacologically plausible: ADHD is associated with anandamide deficiency, CB1 directly modulates dopamine. Survey data shows 55% report better concentration. At a glance: 20-30% of all adults with ADHD self-medicate with cannabis Mechanism: ADHD is associated with anandamide deficiency – CB1 directly modulates dopamine For […]
The most important thing: CBD has been removed from the WADA banned list since 2018 – THC remains banned (150 ng/ml limit in competition). CBD inhibits COX-2 like ibuprofen, improves sleep quality and modulates cortisol – without the risk of tolerance. At a glance: CBD removed from the banned list by WADA in 2018 – […]
The most important thing: THC increases the heart rate by 20-50 bpm by activating the sympathetic nervous system. In healthy boys: harmless. In coronary heart disease: risk of heart attack increases 4.8-fold in the first hour. CBD, on the other hand, lowers blood pressure. At a glance: THC increases the heart rate by 20-50 bpm […]
The most important thing: B cells have the highest CB2 density of all immune cells. CB2 activation by cannabinoids shifts macrophages from pro-inflammatory (M1) to anti-inflammatory (M2) – a central mechanism in autoimmune diseases. At a glance: B cells have the highest CB2 density of all immune cells – ECS is deeply integrated into the […]
The most important thing: cannabis reduces the need for opioids in palliative patients by a median of 44% (Mechnik 2018). Dronabinol and nabilone are approved for chemotherapy nausea. Since 2017 on BtMG prescription with SHI reimbursement option. At a glance: Dronabinol (THC) and nabilone are officially approved for chemotherapy nausea Cannabis reduces the need for […]
The most important thing: CBD inhibits COX-2 – the same enzyme as ibuprofen – and activates CB1 receptors directly in the uterine muscles. It also has an anxiolytic effect via 5-HT1A. Survey data show 7.6/10 efficacy for menstrual pain. At a glance: CBD inhibits COX-2 – the same mechanism as ibuprofen, but without gastrointestinal risk […]
The most important thing: According to the study, full-spectrum cannabis requires a lower dose for the same epilepsy control as CBD isolate (Pamplona 2018). Why? Cannabinoids, terpenes and flavonoids work synergistically – this is the entourage effect. At a glance: Full-spectrum needs lower dose than CBD isolate for same effect, according to study Terpenes such […]
The most important thing: oestrogen directly regulates anandamide levels in the brain. If oestrogen falls during the menopause, anandamide also falls – which explains hot flushes, sleep disorders and mood swings neurobiologically. At a glance: Oestrogen directly regulates anandamide levels – menopause = ECS dysregulation 79% of women surveyed report symptom relief from cannabis (Dahlgren […]
Most importantly, IBS affects 10-15% of the population. IBS patients have increased FAAH activity and lower anandamide levels in the intestine – a measurable ECS deficit directly at the site of the symptoms. At a glance: IBS patients have increased FAAH activity and lower anandamide levels in the gut – measurable ECS deficit CB1 on […]
Most importantly, endometriosis lesions express CB1 and CB2 at lower levels than normal endometrium – an ECS hypoactivity directly at the pathology site. CBD inhibited proliferation and invasion of lesions in vitro (Bouaziz 2017). At a glance: Endometriosis lesions express CB1 and CB2 – ECS directly involved in pathophysiology CBD inhibited proliferation and invasion of […]
The most important thing: THC crosses the placental barrier without any problems. The fetal ECS already develops in the first trimester. No known safe limit – the only evidence-based limit is total abstinence. At a glance: THC crosses the placental barrier and binds to CB1 receptors in the fetal brain from the first trimester onwards […]
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