The most important thing: Chronic back pain has four types of pain (nociceptive, neuropathic, myofascial, centralized) – cannabis attacks all four at the same time. 70% of patients report a strong reduction. And: cannabis can reduce opioid requirements by 44 %. At a glance: Cannabis simultaneously targets all 4 types of pain: nociceptive, neuropathic, myofascial, […]
Most importantly, social anxiety is the best clinically proven cannabis indication. Bergamaschi 2011 (RCT): CBD 600 mg measurably halved anxiety, cognitive impairment and physiological stress during public speaking. THC, on the other hand, can increase social anxiety. At a glance: Bergamaschi 2011 (RCT): CBD 600 mg halved anxiety, cognitive impairment and stress Optimal dose: 300 […]
The most important thing: Restless legs syndrome (RLS) affects 5-10% of the population and is often resistant to treatment. Cannabis intervenes directly in RLS pathophysiology via dopaminergic modulation (CB1 in basal ganglia) and spinal pain processing (TRPV1). At a glance: RLS affects 5-10% of the population and is treatment-resistant in many cases Ghorayeb 2020: 6 […]
The most important thing: CB2 receptors – the non-psychoactive cannabinoid receptor class – are located directly on osteoblasts and osteoclasts. CB2 activation promotes bone formation and inhibits bone resorption. CBD significantly accelerated fracture healing in animal models. At a glance: CB2 receptors are located directly on osteoblasts (bone formation) and osteoclasts (bone resorption) CB2 knockout […]
The most important thing: Daily cannabis use is a problem when trying to conceive: Gundersen 2015 shows up to 52% lower sperm concentration. All effects are reversible after 3 months of abstinence – spermatogenesis takes 74 days. At a glance: Weekly consumption: 28% lower sperm concentration (Gundersen 2015, n=1215) All sperm effects completely reversible after […]
The most important thing: 15-25% of black market cannabis contains pesticides above EU limits. Medical pharmacy cannabis must meet GMP standards and comes with a Certificate of Analysis. Mold on cannabis can be life-threatening for the immunocompromised. At a glance: 15-25% of black market cannabis contains pesticides above EU food limits Pharmacy cannabis: GMP obligation […]
The most important thing: Since the CanG (April 1, 2024), 3 cannabis plants are legal at home. 50 g possession allowed in the home. 25 g may be passed on free of charge. Sale, commercial cultivation and transfer to minors remain criminal offenses. At a glance: Legal since CanG (April 1, 2024): 3 plants at […]
The most important thing: THC has a biphasic effect: 1-5 mg can have an anxiolytic and focusing effect. 20-25 mg+ can trigger paranoia and anxiety. Anyone using cannabis for medicinal purposes needs a minimum dose – not a maximum. At a glance: THC has a biphasic effect: 1-5 mg anxiolytic and focusing, 20+ mg can […]
The most important thing: CBN is formed when THC oxidizes – through UV light, oxygen and heat over months. Old cannabis contains more CBN. CBN is weakly psychoactive and has a sedative effect mainly in combination with THC – not alone. At a glance: CBN is produced exclusively by oxidation of THC – UV light, […]
Most important: 20-30% of all adults with ADHD self-medicate with cannabis. Pharmacologically plausible: ADHD is associated with anandamide deficiency, CB1 directly modulates dopamine. Survey data shows 55% report better concentration. At a glance: 20-30% of all adults with ADHD self-medicate with cannabis Mechanism: ADHD is associated with anandamide deficiency – CB1 directly modulates dopamine For […]
The most important thing: CBG is the biosynthesis precursor of all cannabinoids – CBGA produces THC, CBD and CBC. Only traces are present in mature plants. CBG acts via CB2, α2-adrenoceptors (glaucoma) and has a direct antibacterial effect against MRSA. At a glance: CBG is the biosynthetic precursor of all cannabinoids – CBGA produces THC, […]
The most important thing: raw cannabis flowers do not get you high. THCA (the natural form) hardly binds to CB1 receptors. Only heat (120°C, 35 min) produces active THC through decarboxylation. This happens automatically when smoking. At a glance: Raw cannabis does not get you high – THCA hardly binds to CB1 receptors Optimal decarboxylation: […]
The most important thing: CBD has been removed from the WADA banned list since 2018 – THC remains banned (150 ng/ml limit in competition). CBD inhibits COX-2 like ibuprofen, improves sleep quality and modulates cortisol – without the risk of tolerance. At a glance: CBD removed from the banned list by WADA in 2018 – […]
The most important thing: THC increases the heart rate by 20-50 bpm by activating the sympathetic nervous system. In healthy boys: harmless. In coronary heart disease: risk of heart attack increases 4.8-fold in the first hour. CBD, on the other hand, lowers blood pressure. At a glance: THC increases the heart rate by 20-50 bpm […]
The most important thing: Hirvonen 2012 PET study: Daily cannabis users have 15-20% fewer CB1 receptors in the cortex. This is the neurobiological cause of tolerance. After 4 weeks of abstinence: measurable recovery of receptor density. At a glance: PET study: daily users have 15-20% fewer CB1 receptors in the cortex (Hirvonen 2012) After 4 […]
The most important thing: B cells have the highest CB2 density of all immune cells. CB2 activation by cannabinoids shifts macrophages from pro-inflammatory (M1) to anti-inflammatory (M2) – a central mechanism in autoimmune diseases. At a glance: B cells have the highest CB2 density of all immune cells – ECS is deeply integrated into the […]
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