Most important: Tinnitus is one of the few indications where cannabis may NOT help: CB1 activation in the dorsal cochlear nucleus can increase tinnitus-like activity. Bhatt 2020: Cannabis use associated with increased risk of tinnitus. At a glance: CB1 receptors in auditory cortex and cochlear nuclei – but cannabis can worsen tinnitus Bhatt 2020: Cannabis […]
The most important thing: CBGA is the biosynthetic precursor of all cannabinoids – less than 1% CBG remains in mature plants. Farha 2020: CBG destroyed MRSA biofilms more effectively than many standard antibiotics. At a glance: CBGA is biosynthetic precursor of all cannabinoids – less than 1% CBG left in mature plants Farha 2020: CBG […]
The most important thing: the ECS changes with age: CB1 receptor density decreases, anandamide decreases. People over 65 are the fastest growing group when it comes to medicinal cannabis – and often react more strongly to cannabinoids. At a glance: CB1 receptor density decreases with age – older people react more strongly to cannabinoids Over […]
The most important thing: Chronic stress downregulates CB1 receptors in the prefrontal cortex and hippocampus – directly measurable in burnout pathophysiology. CBD modulates the HPA axis and can lower basal cortisol levels. At a glance: Chronic stress → CB1 downregulation in the prefrontal cortex – measurable ECS deficit in burnout CBD modulates HPA axis and […]
The most important thing: CBN is produced by THC oxidation – not by extraction. CBN alone has no measurable sleep effect. Only CBN+THC combined is measurably more sedating than THC alone (Musty 1976). Many CBN products exaggerate. At a glance: CBN alone = no measurable sleep effect – only CBN+THC combined significantly more sedative CBN […]
The most important thing: THC is a recognized risk factor for mania triggers in bipolar disorder. 40% of bipolar patients use cannabis for self-medication – mostly for depressive phases. Psychiatric consultation is mandatory. At a glance: THC in bipolar disorder = risk factor for mania triggers – no attempt to self-medicate with THC 40% of […]
Most importantly, Alzheimer’s patients have reduced anandamide levels and downregulated CB1 receptors in the entorhinal cortex. CBD inhibits amyloid-β aggregation and tau hyperphosphorylation – both core drivers of the disease. At a glance: CBD inhibits amyloid-β aggregation and tau hyperphosphorylation (in vitro and animal model) CB2 on microglial cells: Cannabis reduces neuroinflammation – a core […]
Most important: CB2 receptors are located directly on inflamed synovial cells and chondrocytes in rheumatism. Blake 2006 (RCT, n=58): Nabiximols significantly better than placebo for pain and disease activity (DAS28). At a glance: CB2 is directly expressed on synovial cells and chondrocytes – cannabis attacks at the site of inflammation Blake 2006 (RCT, n=58): Nabiximols […]
The most important thing: THC inhibits CGRP release from trigeminal nerve endings – the same target as modern migraine biologics (Aimovig, Emgality). Rhyne 2016: Migraine frequency decreased from 10.4 to 4.6 attacks/month (-56 %). At a glance: THC inhibits CGRP – the same target as migraine biologics (Aimovig, Emgality) Rhyne 2016 (n=121): -56% migraine frequency […]
Social Club in Ibiza – Imagine you are on a beautiful island in the Mediterranean Sea and you don’t have the same problems with cannabis as in other countries! Welcome to Ibiza. You are addicted to cannabis or marijuana? Then you shouldn’t ask on the street, but go specifically to a good social club. You […]
Are you planning a trip to Madrid and want to know how the local social clubs work? Then you’ve come to the right place. Madrid is home to some of the most exciting cannabis social clubs in Spain – from Green Paradise to Euphoria. We visited them, shot videos and show you our recommendations here. […]
Barcelona is one of the most famous cities in Europe when it comes to cannabis social clubs. Here you will not only find sun, sea and architecture – but also some of the best clubs in Spain. If you want to watch videos beforehand, get an impression and know where you’re welcome, then you’ve come […]
Seville may not be the first city that comes to mind when you think of cannabis social clubs – but that’s exactly what makes it an insider tip. Away from the tourist crowds, you’ll find real local spots with an authentic atmosphere. Anyone on vacation in Seville should not only explore the old town, but […]
Málaga is sun, beach and relaxed vibes – perfect for a short trip. But did you know that there are also some really good cannabis social clubs here? Between the harbor, the old town and the beach promenade, you’ll find cool spots that you can easily visit as a tourist. All you need is your […]
Have you always wondered how cannabis is grown? Here you get first-hand answers. I watched the whole video from Weedland – a full 20 minutes. And what can I say? You have to watch this video! YouTuber Weedland was out and about on the CannaZen plantation, which we have already introduced to you in the […]
Marbella stands for luxury, beach clubs and celebrity flair – but also for relaxed social clubs with high-quality varieties. If you are on vacation here and looking for moments of pleasure, you will find real insider tips between the marina and the old town. Important: The clubs are usually inconspicuous from the outside – you […]
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