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Cannabis for PMS & menstrual pain
in Cannabis, News/by StephanThe most important thing: CBD inhibits COX-2 – the same enzyme as ibuprofen – and activates CB1 receptors directly in the uterine muscles. It also has an anxiolytic effect via 5-HT1A. Survey data show 7.6/10 efficacy for menstrual pain. At a glance: CBD inhibits COX-2 – the same mechanism as ibuprofen, but without gastrointestinal risk […]
Entourage effect: How cannabinoids & terpenes interact
in Cannabis, News/by StephanThe most important thing: According to the study, full-spectrum cannabis requires a lower dose for the same epilepsy control as CBD isolate (Pamplona 2018). Why? Cannabinoids, terpenes and flavonoids work synergistically – this is the entourage effect. At a glance: Full-spectrum needs lower dose than CBD isolate for same effect, according to study Terpenes such […]
Cannabis during the menopause: CBD, hormones & studies
in Cannabis, News/by StephanThe most important thing: oestrogen directly regulates anandamide levels in the brain. If oestrogen falls during the menopause, anandamide also falls – which explains hot flushes, sleep disorders and mood swings neurobiologically. At a glance: Oestrogen directly regulates anandamide levels – menopause = ECS dysregulation 79% of women surveyed report symptom relief from cannabis (Dahlgren […]
Cannabis edibles: effect, duration & dosage explained
in Cannabis, News/by StephanThe most important thing: THC is converted in the liver to 11-hydroxy-THC – a metabolite that is up to 3× stronger than THC itself. This explains why edibles have a more intense effect and why topping up after 45 minutes is the classic mistake. At a glance: THC → 11-hydroxy-THC in the liver: up to […]
Pferd kaufen: Preise, Kosten & worauf du achten musst — von Warmblut bis Vollblut
in /by StephanPferd kaufen — Preisklassen, Ankaufsuntersuchung, Kaufvertrag und versteckte Kosten im Überblick.
Cannabis & alcohol: combination, risks & crossfade
in Cannabis, News/by StephanMost importantly, alcohol significantly increases gastrointestinal THC absorption. Cannabis + alcohol is not additive – but synergistic. Hartman 2015: The combination doubles driving impairment compared to cannabis alone. At a glance: Alcohol significantly increases the THC plasma concentration (Cmax) – the same dose has a more intensive combined effect Combination of cannabis + alcohol = […]
Stars and their private jets: Kim Kardashian, Taylor Swift & Kylie Jenner
in Celebrities/by StephanPrivate jets are as commonplace for the world’s richest people as cabs are for the rest of us. While we stand in queues, show boarding passes and smuggle miniature shampoos through security checks, Hollywood stars, billionaires and music legends walk straight from their cars onto their own planes. No check-in, no crowds, no schedule except […]
Cannabis for irritable bowel syndrome: IBS, CBD & intestinal pain
in Cannabis, News/by StephanMost importantly, IBS affects 10-15% of the population. IBS patients have increased FAAH activity and lower anandamide levels in the intestine – a measurable ECS deficit directly at the site of the symptoms. At a glance: IBS patients have increased FAAH activity and lower anandamide levels in the gut – measurable ECS deficit CB1 on […]
Professional teeth cleaning: Costs, procedure & when supplementary dental insurance is worthwhile
in Beauty/by StephanProfessional teeth cleaning (PZR) is one of the most important preventive measures for healthy teeth – but the costs are not usually covered by statutory health insurance. What does a PZR really cost, what are the annual costs and when is supplementary dental insurance worthwhile? New from us: Your comparison portal on dental insurance One. […]
Cannabis for endometriosis: pain, CBD & study situation
in Cannabis, News/by StephanMost importantly, endometriosis lesions express CB1 and CB2 at lower levels than normal endometrium – an ECS hypoactivity directly at the pathology site. CBD inhibited proliferation and invasion of lesions in vitro (Bouaziz 2017). At a glance: Endometriosis lesions express CB1 and CB2 – ECS directly involved in pathophysiology CBD inhibited proliferation and invasion of […]