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Cannabis & heart: cardiovascular risks explained
in Cannabis, News/by StephanThe most important thing: THC increases the heart rate by 20-50 bpm by activating the sympathetic nervous system. In healthy boys: harmless. In coronary heart disease: risk of heart attack increases 4.8-fold in the first hour. CBD, on the other hand, lowers blood pressure. At a glance: THC increases the heart rate by 20-50 bpm […]
THC tolerance: how it develops and how to reduce it
in Cannabis, News/by StephanThe most important thing: Hirvonen 2012 PET study: Daily cannabis users have 15-20% fewer CB1 receptors in the cortex. This is the neurobiological cause of tolerance. After 4 weeks of abstinence: measurable recovery of receptor density. At a glance: PET study: daily users have 15-20% fewer CB1 receptors in the cortex (Hirvonen 2012) After 4 […]
Cannabis & immune system: CB2 receptors & inflammation
in Cannabis, News/by StephanThe most important thing: B cells have the highest CB2 density of all immune cells. CB2 activation by cannabinoids shifts macrophages from pro-inflammatory (M1) to anti-inflammatory (M2) – a central mechanism in autoimmune diseases. At a glance: B cells have the highest CB2 density of all immune cells – ECS is deeply integrated into the […]
Arabisches Vollblut: Die älteste Edelrasse der Welt — Charakter, Preise & Haltung
in /by StephanArabisches Vollblut: Geschichte, Rassmerkmale, Charakter und Kaufpreise der ältesten Edelrasse der Welt.
Cannabis in palliative care: pain & quality of life
in Cannabis, News/by StephanThe most important thing: cannabis reduces the need for opioids in palliative patients by a median of 44% (Mechnik 2018). Dronabinol and nabilone are approved for chemotherapy nausea. Since 2017 on BtMG prescription with SHI reimbursement option. At a glance: Dronabinol (THC) and nabilone are officially approved for chemotherapy nausea Cannabis reduces the need for […]
Equestrian Luxury: Hermès, Pikeur, Samshield & the best brands for riders
in /by StephanLuxury riding gear: Hermès saddles, Pikeur fashion, Samshield helmets — all top brands and prices.
Delta-8-THC & Delta-10-THC: Effect, difference & law
in Cannabis, News/by StephanThe most important thing: Delta-8-THC is not a natural cannabis substance – it is almost exclusively produced synthetically from CBD. FDA analysis 2021 found dangerous impurities. In Germany it is not “legal THC” – legally it is considered a narcotic. At a glance: Delta-8-THC hardly occurs naturally in plants – almost all products are produced […]
Cannabis forms of consumption: Joint, vaporizer, oil & concentrates
in Cannabis, News/by StephanThe most important thing: vaporizers deliver 40-56 % bioavailability compared to 25 % with a joint – without tar, without CO, without benzenes. For medical users, vaporizer or sublingual oil is the most pharmacologically sensible way. At a glance: Vaporizer delivers 40-56 % bioavailability – more than twice as efficient as a joint Sublingual oil: […]
Cannabis & body weight: Why stoners are slim
in Cannabis, News/by StephanThe most important thing: although cannabis increases appetite, users have on average 25% lower obesity rates than non-users. Background: chronic use leads to CB1 downregulation and increased adiponectin. At a glance: Paradox: Cannabis users have 25% lower obesity rates than non-users Chronic use → CB1 downregulation → Metabolic reset of the ECS CBD converts white […]
Keeping a horse costs: Monthly expenses for stable, vet & equipment
in /by StephanKeeping a horse costs: boarding stable, vet, farrier, equipment — an overview of all monthly expenses.