Cannabis during pregnancy and breastfeeding: Risks

Cannabis is considered “natural” — and precisely for this reason, some pregnant women underestimate the risk. In fact, cannabis during pregnancy is one of the few topics where scientific evidence is clear and consistent: THC reaches the fetus directly and can permanently influence brain development.

Why THC is particularly risky for fetuses

The endocannabinoid system (ECS) plays a central role in fetal development — long before birth:

  • ECS in fetal development: CB1 and CB2 receptors are already active in early embryonic development (from 5th to 6th week of pregnancy). Endocannabinoids regulate neuron migration, synapse formation, and cortical maturation
  • THC as a disruptive factor: THC mimics anandamide and interferes with these developmental signals. In animal models, prenatal application of THC permanently disrupts correct neuron migration and synaptogenesis
  • Sensitive window: The first trimester is particularly critical — during this phase, fundamental brain architectures are established. However, the second and third trimesters are also not safe — neuronal pruning and myelination continue well beyond birth

THC Transfer: Placenta and Breast Milk

THC is lipophilic — it crosses biological barriers with particular efficiency:

  • Placental transfer: THC crosses the placental barrier. Studies show detection of THC in fetal blood in consuming mothers. The placental concentration is approximately 10–30% of the maternal plasma concentration
  • Breast milk: THC accumulates in breast milk — due to its lipophilic nature, resulting in higher concentrations than in plasma. Studies (Eidelman & Baker 2016, Bertrand 2018) show detection of THC in breast milk from consuming mothers even days to weeks after the last consumption
  • Infant exposure: A breastfed child takes up about 0.8% of the mother’s THC dose through breast milk — sounds low, but the weight ratio makes the difference: A 5-kg infant receives significantly more THC per kg of body weight than the mother
  • CBD: CBD also crosses the placenta and enters breast milk — safety data for CBD during pregnancy are still insufficient, so it is not recommended either

Documented Risks for the Child

Epidemiological studies show consistent findings:

  • Birth weight: Prenatal cannabis use is associated with an increased risk of low birth weight (under 2500 g) and preterm birth — several meta-analyses confirm this
  • Neurocognitive development: ABCD Study (Adolescent Brain Cognitive Development, n>11,000): Children exposed to cannabis prenatally show significantly worse cognitive test results, more behavioral problems, and higher rates of anxiety disorders and ADHD symptoms at the age of 9–10 years
  • Ottawa Prenatal Prospective Study: Long-term follow-up (30+ years): Prenatal cannabis exposure correlates with poorer school performance, attention problems, and increased risk of substance use in adulthood
  • Sleep architecture in newborns: Studies show altered sleep patterns in newborns of mothers who use cannabis — ECS dysregulation as a possible mechanism

Common Misconceptions

Why cannabis is consumed during pregnancy despite the risks:

  • “Natural = safe”: Natural origin does not mean a safety certificate. Alcohol and nicotine are also “natural” and highly risky during pregnancy
  • “Against nausea in pregnancy”: Increasingly common in the US — cannabis for hyperemesis gravidarum. Evidence of effectiveness is lacking, and fetal risk is documented. Medically approved antiemetics (ondansetron, promethazine) are safer
  • “Occasional use is okay”: There is no safe threshold for prenatal cannabis use. The first trimester is particularly critical, but no point during pregnancy is “safe”
  • “CBD is safe”: CBD safety data during pregnancy are insufficient. The WHO and EMA explicitly do not recommend CBD during pregnancy

Recommendations and Alternatives

  • Complete abstinence: All medical societies (WHO, ACOG, DGGG) recommend complete cannabis abstinence during pregnancy and breastfeeding
  • Nausea during pregnancy: Ginger (1 g/day, evidence-based), vitamin B6, acupressure wristbands, and approved antiemetics under medical supervision in severe cases
  • Anxiety/sleep during pregnancy: Progressive muscle relaxation, pregnancy yoga, cognitive behavioral therapy — without pharmaceutical interventions
  • If currently used: Immediate need for a conversation with a gynecologist — no judgment, but support. Many practices have experience with this conversation

How THC enters and is broken down in the body — basics: Cannabis Effect and ECS. Why teenagers and young brains are especially at risk: Cannabis and Teenagers. Cannabis and hormones — what THC does to the body: Cannabis and Hormones.

Frequently asked questions about cannabis during pregnancy and breastfeeding