Cannabis for obsessive-compulsive disorder: OCD, CBD & serotonin

Most importantly, the ECS regulates extinction learning and habitualization – precisely the processes that are dysfunctional in OCD. CB1 in the orbitofrontal cortex and striatum inhibits the hyperactive CSTC circuit typical of OCD. At a glance: CB1 in the orbitofrontal cortex and striatum inhibits the OCD-typical hyperactive CSTC circuit Kayser 2021: Nabilone (synthetic THC) significantly […]

Cannabis for high blood pressure: CBD lowers, THC increases briefly

The most important thing: CBD lowers blood pressure, THC increases it in the short term. Jadoon 2017 (RCT, n=9): Single CBD dose 600 mg lowered systolic blood pressure at rest by -6 mmHg. Over 30 million Germans have hypertension. At a glance: CBD lowers blood pressure: -6 mmHg systolic at rest (Jadoon 2017, RCT) and […]

CBD for dogs & cats: Effect, dose & safety

The most important thing: all mammals have an ECS. But dogs are hypersensitive to THC: significantly more CB1 receptors in the cerebellum than humans, slower metabolization. Even small amounts of THC can lead to severe intoxication. At a glance: Dogs have significantly more CB1 receptors in the cerebellum than humans – THC is toxic to […]

Cannabis Social Club: Become a member – application & costs

The most important thing: Cannabis social clubs (cultivation associations) have been legal in Germany since July 1, 2024. Up to 500 members, non-profit, maximum 25 g distribution/day or 50 g/month. No sale – only cost recovery. At a glance: Legal since July 1, 2024 – maximum 500 members, non-profit, distribution up to 25 g/day No […]

Cannabis for tinnitus: CB1, CBD & studies at a glance

Most important: Tinnitus is one of the few indications where cannabis may NOT help: CB1 activation in the dorsal cochlear nucleus can increase tinnitus-like activity. Bhatt 2020: Cannabis use associated with increased risk of tinnitus. At a glance: CB1 receptors in auditory cortex and cochlear nuclei – but cannabis can worsen tinnitus Bhatt 2020: Cannabis […]

CBG: The cannabinoid strain – effects, research & application

The most important thing: CBGA is the biosynthetic precursor of all cannabinoids – less than 1% CBG remains in mature plants. Farha 2020: CBG destroyed MRSA biofilms more effectively than many standard antibiotics. At a glance: CBGA is biosynthetic precursor of all cannabinoids – less than 1% CBG left in mature plants Farha 2020: CBG […]

Cannabis for seniors: pain, sleep & risks from 65

The most important thing: the ECS changes with age: CB1 receptor density decreases, anandamide decreases. People over 65 are the fastest growing group when it comes to medicinal cannabis – and often react more strongly to cannabinoids. At a glance: CB1 receptor density decreases with age – older people react more strongly to cannabinoids Over […]

Cannabis for burnout: HPA axis, cortisol & ECS

The most important thing: Chronic stress downregulates CB1 receptors in the prefrontal cortex and hippocampus – directly measurable in burnout pathophysiology. CBD modulates the HPA axis and can lower basal cortisol levels. At a glance: Chronic stress → CB1 downregulation in the prefrontal cortex – measurable ECS deficit in burnout CBD modulates HPA axis and […]

Gulfstream G650ER: The private jet of the stars – Kim Kardashian, Oprah and Co.

The Gulfstream G650ER is more than just an airplane – it is the symbol of freedom of movement at the highest level. With a range of over 13,000 kilometers and a cruising speed close to Mach 0.9, it is one of the fastest and most far-reaching private jets in the world. Kim Kardashian, Oprah Winfrey, […]

CBN: The sleep cannabinoid – effects, studies & dosage

The most important thing: CBN is produced by THC oxidation – not by extraction. CBN alone has no measurable sleep effect. Only CBN+THC combined is measurably more sedating than THC alone (Musty 1976). Many CBN products exaggerate. At a glance: CBN alone = no measurable sleep effect – only CBN+THC combined significantly more sedative CBN […]