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Cannabis for diabetes: blood sugar, insulin & ECS
in Cannabis, News/by StephanMost importantly, cannabis users paradoxically have 16% lower fasting insulin levels and 17% lower insulin resistance than non-users (NHANES, n=4657). The ECS is directly integrated into glucose metabolism. At a glance: Paradox: Cannabis users have 16% lower insulin levels despite increased appetite (Penner 2013) CB1 and CB2 on pancreatic beta cells – cannabis intervenes directly […]
Cannabis for nausea: chemo, antiemetic & studies
in Cannabis, News/by StephanMost important: Dronabinol (synthetic THC) received FDA approval in 1985 for chemotherapy nausea – one of the oldest medical cannabis indications. CB1 in the vomiting center (area postrema) directly inhibits the serotonergic nausea signaling cascade. At a glance: Dronabinol FDA-approved for chemotherapy nausea since 1985 – one of the oldest cannabis indications CB1 in the […]
Cannabis for fibromyalgia: pain, sleep & CBS theory
in Cannabis, News/by StephanMost importantly, fibromyalgia patients have been shown to have lower levels of anandamide in the CSF – a direct ECS deficit. CEDS theory (Russo 2016): Fibromyalgia, migraine and irritable bowel syndrome may be endocannabinoid-deficient disorders. At a glance: Fibromyalgia patients have been shown to have lower anandamide levels – direct ECS deficit in CSF CEDS […]
Cannabis for asthma & COPD: vaporizers instead of smoking
in Cannabis, News/by StephanMost important: Cannabis smoking is contraindicated in asthma and COPD. But: THC has bronchodilatory properties via CB1 on bronchial muscle cells. Vaporizers are the only sensible form of inhalation for lung diseases. At a glance: THC has bronchodilatory effect via CB1 – but ONLY when not smoked Cannabis smoking: contraindicated in asthma and COPD – […]
CBD dosage: The complete guide for all indications
in Cannabis, News/by StephanThe most important thing: CBD has no standard dosage. Optimal dose depends on indication, body weight, CYP metabolism and form of administration. U-shaped dose-response curve: for anxiety, 300 mg is better than 600 mg. At a glance: CBD has no standard dosage – optimal dose is indication- and person-specific U-shaped effect curve for anxiety: 300 […]
Cannabis baking: Brownies, cookies & recipes for the kitchen
in Cannabis/byBaking cannabis is an art form. Anyone who has ever made their own space brownies or cannabis cookies knows that the trick is not in the recipe alone – but in the preparation. If you know the basics, you will achieve consistent results and know what you are eating. How does cannabis work in baking? […]
Cannabis addiction: addiction, withdrawal & quitting explained
in Cannabis, News/by StephanThe most important thing: 9% of users develop a cannabis addiction – compared to 32% for nicotine, 23% for heroin and 15% for alcohol. Daily users: 25-50 % risk. Dependence is real, but substance-specific lower. At a glance: 9% of users develop dependence (vs. 32% nicotine, 23% heroin, 15% alcohol) Daily use: 25-50% risk of […]
Cannabis and sleep: REM, deep sleep & melatonin explained
in Cannabis, News/by StephanThe most important thing: THC shortens sleep onset time, suppresses REM sleep and increases deep sleep. CBD high dose (160+ mg) increases total sleep time. After T-break: REM rebound with intense dreams for 1-3 weeks. At a glance: THC: shortens sleep onset time, suppresses REM, increases deep sleep – good in the short term, problematic […]
Cannabis worldwide: Laws in the USA, Canada & Europe
in Cannabis, News/by StephanThe most important thing: Cannabis laws vary extremely around the world: from full legalization (Canada, Uruguay) to the death penalty (Singapore, Malaysia). Since April 2024, Germany has been one of the few countries in the EU with limited recreational legalization. At a glance: Germany since April 2024: possession up to 25 g and 3 plants […]
Smoking cannabis and lungs: risks, studies & alternatives
in Cannabis, News/by StephanThe most important thing: cannabis smoke contains the same toxins as tobacco smoke (CO, PAH, benzene, tar) – but there is no evidence of an increased risk of lung cancer. Chronic bronchitis is well documented. Vaporizer solves both problems. At a glance: Cannabis smoke = same toxins as tobacco (CO, PAH, benzene) – but no […]