Pills instead of injections for weight loss: Rybelsus vs Ozempic

There is a new trend in the world of weight loss medication: the choice between pills and injections. While Ozempic is known as a weekly weight loss injection, Rybelsus offers a daily tablet form with the same active ingredient, semaglutide. But which option is better? In this article, we compare both options and take a look at how they work, what they cost and what side effects can occur. Also included: an exciting video that explains the mechanisms of semaglutide. Tip! Everyone knows Ozempic as a weight loss injection, but what else is there? Discover a comparison of weight loss injections 2025 here.

Revolution? Pill instead of injection

Here is the news, below more facts about how the weight loss injections and pills work! Unlike Ozempic, Wegovy, Saxenda, Trulicity, Victoza or Mounjaro, here you take a pill, you don’t have to inject yourself.

The active substance semaglutide: similarities between Rybelsus and Ozempic

Both Rybelsus and Ozempic are based on semaglutide. This drug mimics a natural hormone that plays a key role in regulating blood sugar and appetite:

• It stimulates insulin production when blood sugar is elevated.
• It inhibits glucose production in the liver.
• It slows down gastric emptying, resulting in a longer feeling of satiety.
• It reduces the feeling of hunger by sending satiety signals to the brain.

Studies show that Semaglutide is very effective for both diabetes and weight loss. Users lose an average of 10-20% of their body weight over a period of 12-18 months.

Rybelsus: The advantages of the pill

Rybelsus is the first oral alternative to weight loss injections such as Ozempic. The active ingredient is stabilized by a special technology so that it can be absorbed in the gastrointestinal tract. Advantages of Rybelsus:

• No injections: Ideal for people who don’t like injections.
• Daily intake: Easy to integrate into everyday life.
• Equally effective as Ozempic for weight loss and blood sugar control.

It is taken in the morning on an empty stomach with a little water. Afterwards, you should not eat or drink for 30 minutes in order to maximize the absorption of the active ingredient.

Ozempic: The advantages of the syringe

Ozempic is a weekly weight loss injection that is also based on semaglutide. The advantages:

• Only necessary once a week: Less effort compared to the daily pill.
• Automatic dosing system: Minimizes the risk of ingestion errors.
• Proven method: successfully in use for years.

The injection is made into the abdomen, thigh or upper arm. Many users appreciate the easy handling of the pre-filled pen.

Differences in costs and side effects

Costs

Both drugs are not cheap. The monthly costs are around 250-300 euros, depending on dosage and insurance. Rybelsus and Ozempic are often only reimbursed for the treatment of type 2 diabetes; in the case of pure weight reduction, the costs usually have to be borne by the patient.

Side effects

Both drugs can have similar side effects, including

• Nausea, especially at the start of therapy
• Digestive problems such as constipation or diarrhea
• Occasionally tiredness or headaches

The choice between the pill and the injection can also depend on individual experience of side effects.

Which is better: Rybelsus or Ozempic?

The choice between Rybelsus and Ozempic depends on your personal preferences and lifestyle:

• Rybelsus: Ideal for people who don’t like injections and can remember to take them every day.
• Ozempic: Perfect for users who prefer a weekly rhythm and want a proven method.

Both medications are effective and safe as long as they are used under medical supervision. Your doctor can help you find the best option for your needs.

Conclusion: The right choice for you

Rybelsus and Ozempic offer different benefits and make the use of semaglutide more flexible than ever. Whether you choose the pill or the injection depends on your individual preferences and lifestyle. It is important that you seek advice from a doctor and only use the medication in accordance with medical guidelines.

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Weight loss injection 1×1

Learn everything you need to know about the various weight loss injections here. But remember, they can only help you on your way. To lose weight in the long term, you need to know your basal metabolic rate (calorie requirement) so that you can maintain your desired weight! So be sure to take a look at my “Weight loss tips”, which I have linked here for you:

• Comparison of syringes
• Ozempic slimming syringe
• Slimming tips