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Cannabis Tolerance: Explained: CB1 Downregulation, T-Break and Reset
in /byRegular cannabis consumers know the phenomenon: after weeks or months, you need significantly more for the same effect — or there is no effect at all. Cannabis tolerance is not a myth, but a measurable neurobiological process. What happens, how quickly it happens, and how to counteract it. What is cannabis tolerance? The molecular basis […]
Cannabis Terpenes: Myrcene, Linalool, β-Caryophyllene and the Entourage Effect
in /byTwo strains with identical THC content can have completely different effects — a phenomenon that has long puzzled cannabis research. The answer lies to a large extent in the terpenes: volatile aromatic compounds that not only determine the scent but also directly influence the effect. Anyone choosing strains deliberately cannot avoid terpene profiles. What are […]
Cannabis and Cancer: Antitumor Effects, Palliative Therapy and Evidence
in /byCannabis and cancer — few topics are more emotionally charged and surrounded by more misinformation. On one side, there are healing promises without evidence, on the other side, conservative medicine overlooks real palliative uses. This article clearly distinguishes between preclinical anti-tumor findings, what of that is clinically relevant, and the proven palliative medical benefits. Anti-tumor […]
Cannabis in Parkinson’s disease: Tremor, basal ganglia and what studies show
in /byParkinson is the second most common neurodegenerative disease after Alzheimer’s — approximately 400,000 people affected live in Germany. Standard therapies such as Levodopa slow down symptoms, but cannot stop neurodegeneration and cause their own problems over time. Cannabis is emerging as a complementary treatment option because the endocannabinoid system is embedded in the basal ganglia […]
Cannabis and ADHD: Dopamine, Self-Medication and What Studies Show
in /byADHD (Attention Deficit Hyperactivity Disorder) affects approximately 5% of adults in Germany — many undiagnosed. A strikingly high number of ADHD patients use cannabis for self-medication. Science is investigating whether there is a biologically plausible mechanism behind this — and what it means for medical prescriptions. ADHD Pathophysiology: The Dopamine Deficit ADHD is not a […]
Cannabis for Fibromyalgia: Pain, Sleep and the Endocannabinoid System
in /byFibromyalgia is one of the most common chronic pain syndromes — and one of the most difficult to treat. Standard therapies fail in a large proportion of affected individuals. Cannabis is increasingly coming into focus as a therapeutic option because the endocannabinoid system directly influences pain processing and sleep regulation in fibromyalgia. What is Fibromyalgia? […]
Cannabis for nausea and chemotherapy: Nabilon and Dronabinol
in /byChemotherapy-induced nausea and vomiting (CINV) are among the most burdensome side effects of cancer treatment. Cannabinoids are the oldest pharmacologically developed antiemetics with approved preparations — and yet they are still underutilized in practice. What Dronabinol and Nabilone achieve and when they are indicated. CINV: The Problem Chemotherapy-associated nausea is more complex than a simple […]
Cannabis in Multiple Sclerosis: Sativex, Spasticity and Evidence
in /byMultiple sclerosis is after chronic pain and nausea one of the most common indications for medical cannabis in Germany. With Sativex (Nabiximols), an approved cannabinoid preparation specifically for MS patients exists. How it works, which studies exist, and what affected individuals need to consider when applying for it. Sativex: The first approved cannabis spray worldwide […]
Cannabis and Epilepsy: CBD, Epidiolex, and the State of Research
in /byEpilepsy was one of the first breakthroughs for medical cannabis in modern medicine — and the area where the scientific evidence is strongest. With Epidiolex (pure CBD), the first cannabis-based medication was approved by the FDA and EMA for the treatment of certain forms of epilepsy. What this milestone means, how CBD affects seizures, and […]
Making Your Own Cannabis Oil: Decarboxylation and Infusion
in /bySince legalization, the production of cannabis oil and butter from homegrown plants (up to 3 plants) is legal. Homemade products are cheaper than ready-made products and allow control over the raw materials. Important: Dosage of homemade products is complex and requires caution. Step 1: Decarboxylation — The most important preparation step Raw cannabis is not […]