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Sleep phases explained: REM, deep sleep & what happens in your body every night
in /by StephanSleep feels like a single, unified state – but it is not. Every night, your body goes through several sleep cycles with clearly defined phases in which different biological processes take place. The Cleveland Clinic and the National Sleep Foundation have precisely described these phases. The Sleep Cycle: 90–120 Minutes, 4–5 Times per Night A […]
Better sleep: What doctors really recommend – causes, phases & tips
in /by StephanApproximately one third of all people regularly struggle with sleep problems. This is not a personal weakness – but a well-researched medical phenomenon. Doctors from the Harvard Medical School, the Cleveland Clinic, the National Sleep Foundation, and German sleep experts agree: With the right measures, sleep quality can be significantly improved. This page summarizes what […]
GLP-1 Weight Loss Injection: Comparison of Ozempic, Mounjaro and Wegovy
in /by StephanGLP-1 receptor agonists are a class of medications originally developed for the treatment of type 2 diabetes. Since 2023, compounds such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) have become the focus of growing public interest — not least due to their significant effect on body weight. They mimic the endogenous hormone GLP-1 (glucagon-like peptide-1), […]
Cannabis bei Neuropathie: Neuropathischer Schmerz und CBD
in /byNeuropathischer Schmerz — brennend, einschießend, mit Allodynie und Hyperpathie — spricht auf klassische Analgetika oft unzureichend an. Cannabis gehört zu den wenigen Substanzklassen, für die eine spezifische Wirkung auf neuropathische Schmerzpathways gut belegt ist. CB1, CB2 und TRPV1 sind im nozizeptiven System direkt integriert. Neuropathischer Schmerz: Typen und Pathophysiologie Neuropathischer Schmerz entsteht durch Schädigung oder […]
Buy CBD Oil: A Guide to Quality, Dosage and Full Spectrum
in /byThe CBD oil market is confusing: hundreds of products, varying percentage indications, confusing terms like full spectrum, broad spectrum, and isolate — and barely any government oversight. Anyone who wants to buy CBD oil needs an understanding of the essential quality features. This guide explains what really matters. Was bedeutet die Prozentangabe: CBD-Gehalt berechnen The […]
Cannabis for Sleep Apnea: Dronabinol, Airways and Sleep
in /bySleep apnea is one of the most common sleep-related breathing disorders — and surprisingly, one of the best-researched areas in which synthetic THC (dronabinol) shows positive effects in randomized studies. At the same time, normal cannabis can worsen sleep apnea when misused. The difference lies in mechanism, dosage, and method of administration. Sleep Apnea Physiology: […]
Cannabis and the Liver: Hepatitis, Fibrosis and CBD
in /byThe endocannabinoid system is deeply integrated into liver physiology — with a remarkable peculiarity: CB1 on liver cells promotes fibrosis and steatosis, while CB2 on liver macrophages has anti-fibrotic and hepatoprotective effects. THC activates both receptors, whereas CBD modulates the system through other pathways. What hepatology knows about the liver effects of cannabis. ECS in […]
Cannabis after Stroke: Neuroprotection, CBD and Ischemia
in /byStroke is one of the most common causes of long-term neurological disability — and the endocannabinoid system plays a central role in stroke pathophysiology. CBD shows pronounced neuroprotective effects in preclinical models: reduced infarct size, less excitotoxicity, dampened neuroinflammation. THC, on the other hand, is contraindicated during the acute phase. What the research shows and […]
Cannabis and PTSD: Trauma, Endocannabinoid and Fear Memories
in /byPosttraumatic stress disorder (PTSD) is among the indications for which medical cannabis shows the strongest clinical evidence — and for which the endocannabinoid system plays a central neurobiological role. CB1 receptors directly regulate the extinction of fear memories: the core process of every PTSD therapy. What neuroscience explains and what studies show. ECS and Fear […]
Cannabis for Depression: CBD, Serotonin, and Mood
in /byDepression is one of the most common indications for which people try Cannabis — especially CBD — on their own. Science provides plausible mechanisms, but also clear limits: CBD shows antidepressant properties in animal and early human studies. THC, on the other hand, can temporarily alleviate depression, but may exacerbate it in the long term. […]