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Cannabis for Alzheimer’s & dementia: CBD, neuroprotection & ECS
in Cannabis, News/by StephanMost importantly, Alzheimer’s patients have reduced anandamide levels and downregulated CB1 receptors in the entorhinal cortex. CBD inhibits amyloid-β aggregation and tau hyperphosphorylation – both core drivers of the disease. At a glance: CBD inhibits amyloid-β aggregation and tau hyperphosphorylation (in vitro and animal model) CB2 on microglial cells: Cannabis reduces neuroinflammation – a core […]
Cannabis for rheumatism & arthritis: CB2, inflammation & studies
in Cannabis, News/by StephanMost important: CB2 receptors are located directly on inflamed synovial cells and chondrocytes in rheumatism. Blake 2006 (RCT, n=58): Nabiximols significantly better than placebo for pain and disease activity (DAS28). At a glance: CB2 is directly expressed on synovial cells and chondrocytes – cannabis attacks at the site of inflammation Blake 2006 (RCT, n=58): Nabiximols […]
Cannabis for Migraine: CB1, CGRP & Studies
in /by StephanThe essentials: THC inhibits CGRP release from trigeminal nerve endings – the same target as modern migraine biologics (Aimovig, Emgality). Rhyne 2016: migraine frequency dropped from 10.4 to 4.6 attacks/month (−56%). At a glance: THC inhibits CGRP – the same target as migraine biologics (Aimovig, Emgality) Rhyne 2016 (n=121): −56% migraine frequency with medical cannabis […]
Cannabis for Migraine: CB1, CGRP & Studies
in /by StephanThe Most Important: THC inhibits CGRP release from trigeminal nerve endings – the same target as modern migraine biologics (Aimovig, Emgality). Rhyne 2016: Migraine frequency decreased from 10.4 to 4.6 attacks/month (−56 %). At a Glance: THC inhibits CGRP – the same target as migraine biologics (Aimovig, Emgality) Rhyne 2016 (n=121): −56 % migraine frequency […]
Cannabis for Migraine: CB1, CGRP & Studies
in /by StephanThe Most Important: THC inhibits CGRP release from trigeminal nerve endings – the same target as modern migraine biologics (Aimovig, Emgality). Rhyne 2016: Migraine frequency decreased from 10.4 to 4.6 attacks/month (−56 %). At a Glance: THC inhibits CGRP – the same target as migraine biologics (Aimovig, Emgality) Rhyne 2016 (n=121): −56 % reduction in […]
Cannabis for Migraine: CB1, CGRP & Studies
in /by StephanThe Most Important: THC inhibits CGRP release from trigeminal nerve endings – the same target as modern migraine biologics (Aimovig, Emgality). Rhyne 2016: Migraine frequency decreased from 10.4 to 4.6 attacks/month (−56 %). At a Glance: THC inhibits CGRP – the same target as migraine biologics (Aimovig, Emgality) Rhyne 2016 (n=121): −56 % reduction in […]
Cannabis for Migraine: CB1, CGRP & Studies
in /by StephanThe Most Important: THC inhibits CGRP release from trigeminal nerve endings – the same target as modern migraine biologics (Aimovig, Emgality). Rhyne 2016: Migraine frequency decreased from 10.4 to 4.6 attacks/month (−56 %). At a Glance: THC inhibits CGRP – the same target as migraine biologics (Aimovig, Emgality) Rhyne 2016 (n=121): −56 % reduction in […]
Cannabis for Anxiety Disorders: Effects, Strains & Dosage
in /by StephanAnxiety disorders are the most common mental illnesses in Germany after depression — and one of the most common reasons why people apply for a cannabis prescription. At the same time, cannabis can worsen anxiety. This paradox is explained by dosage, strain, and individual response. Here’s what you need to know. How cannabis affects anxiety: […]
Cannabis for ADHD: Effects, Strains & Current Research Status
in /by StephanCannabis and ADHD — a combination that is hotly debated in the scientific community. For many adults with ADHD, cannabis is the first substance that actually provides relief where methylphenidate or amphetamine cause strong side effects or do not help. What science has to say and which strains could be suitable. ADHD and the Endocannabinoid […]
Cannabis Social Clubs Germany: Cultivation Associations since 2024
in /by StephanSince July 2024, cannabis cultivation associations are legal in Germany. What has worked in Spain for decades is now also possible here — although under stricter conditions. How a cannabis social club works in Germany, what members receive, and how this relates to home cultivation, we explain in detail here. What is a cannabis cultivation […]