Cannabis for fibromyalgia: pain, sleep & CBS theory

Most importantly, fibromyalgia patients have been shown to have lower levels of anandamide in the CSF – a direct ECS deficit. CEDS theory (Russo 2016): Fibromyalgia, migraine and irritable bowel syndrome may be endocannabinoid-deficient disorders. At a glance: Fibromyalgia patients have been shown to have lower anandamide levels – direct ECS deficit in CSF CEDS […]

Cannabis for asthma & COPD: vaporizers instead of smoking

Most important: Cannabis smoking is contraindicated in asthma and COPD. But: THC has bronchodilatory properties via CB1 on bronchial muscle cells. Vaporizers are the only sensible form of inhalation for lung diseases. At a glance: THC has bronchodilatory effect via CB1 – but ONLY when not smoked Cannabis smoking: contraindicated in asthma and COPD – […]

CBD dosage: The complete guide for all indications

The most important thing: CBD has no standard dosage. Optimal dose depends on indication, body weight, CYP metabolism and form of administration. U-shaped dose-response curve: for anxiety, 300 mg is better than 600 mg. At a glance: CBD has no standard dosage – optimal dose is indication- and person-specific U-shaped effect curve for anxiety: 300 […]

Cannabis Space Brownies frisch aus dem Ofen

Cannabis baking: Brownies, cookies & recipes for the kitchen

Baking cannabis is an art form. Anyone who has ever made their own space brownies or cannabis cookies knows that the trick is not in the recipe alone – but in the preparation. If you know the basics, you will achieve consistent results and know what you are eating. How does cannabis work in baking? […]

Cannabis addiction: addiction, withdrawal & quitting explained

The most important thing: 9% of users develop a cannabis addiction – compared to 32% for nicotine, 23% for heroin and 15% for alcohol. Daily users: 25-50 % risk. Dependence is real, but substance-specific lower. At a glance: 9% of users develop dependence (vs. 32% nicotine, 23% heroin, 15% alcohol) Daily use: 25-50% risk of […]

Cannabis and sleep: REM, deep sleep & melatonin explained

The most important thing: THC shortens sleep onset time, suppresses REM sleep and increases deep sleep. CBD high dose (160+ mg) increases total sleep time. After T-break: REM rebound with intense dreams for 1-3 weeks. At a glance: THC: shortens sleep onset time, suppresses REM, increases deep sleep – good in the short term, problematic […]

Cannabis worldwide: Laws in the USA, Canada & Europe

The most important thing: Cannabis laws vary extremely around the world: from full legalization (Canada, Uruguay) to the death penalty (Singapore, Malaysia). Since April 2024, Germany has been one of the few countries in the EU with limited recreational legalization. At a glance: Germany since April 2024: possession up to 25 g and 3 plants […]

Smoking cannabis and lungs: risks, studies & alternatives

The most important thing: cannabis smoke contains the same toxins as tobacco smoke (CO, PAH, benzene, tar) – but there is no evidence of an increased risk of lung cancer. Chronic bronchitis is well documented. Vaporizer solves both problems. At a glance: Cannabis smoke = same toxins as tobacco (CO, PAH, benzene) – but no […]

Cannabis for obsessive-compulsive disorder: OCD, CBD & serotonin

Most importantly, the ECS regulates extinction learning and habitualization – precisely the processes that are dysfunctional in OCD. CB1 in the orbitofrontal cortex and striatum inhibits the hyperactive CSTC circuit typical of OCD. At a glance: CB1 in the orbitofrontal cortex and striatum inhibits the OCD-typical hyperactive CSTC circuit Kayser 2021: Nabilone (synthetic THC) significantly […]

Cannabis recipe free? Price comparison + voucher codes

Doctor, recipe, pharmacy and delivery for patients – did you know how easy it can be? Here you’ll find the most popular providers where you can get Cannabis recipes, online doctors and pharmacies all in one place + gift codes, so you can get your cannabis prescription for free. You don’t need to go to […]